Insulin signaling also controls mTOR pathway that inhibits autophagy.

Insulin signaling also controls mTOR pathway that inhibits autophagy.

Insulin signaling also controls mTOR pathway that inhibits autophagy. Both insulin resistance in Type 2 Diabetes and Alzheimer’s disease impairs the formation of autophagosomes and disrupts lysosomal function. Autophagosomes fuse with lysosomes to form autolysosomes. These autolysosomes have impaired lysosomal function in AD and T2DM and accumulate Aβ and tau aggregates. Undigested toxic aggregates are secreted out of the neurons and propagate toxic oligomers in adjacent neurons.