(Slide) Spliced Peptides — Novel Candidates for Effective Influenza Immunity? [2018-06-27. Patricia Therese Illing. Monash University]

This Monash University slide explains peptide splicing, in a lecture by Dr. Laura Mackay, winner of a 2018 Michelson Prize

This novel class of peptides called spliced peptides are created in the proteasome by a process called transpeptidation which stitches different peptides together. This creates a much more diverse array of proteins that are presented on the surface of the cell with HLAI. New mass spectrometry techniques have revealed that approximately 30% of immunopeptidome peptides were created by peptide splicing. (Credit: Dr. Patricia Therese Illing / Monash University)