Engineered T Cells to Fight Cancer: T Cell Receptor (TCR)
TCRs are proteins that allow T cells to identify cancer targets presented on the surface of cancer cells or inside cancer cells. Endogenous TCRs that are specific to a cancer can be isolated and then engineered into a large number of T cells that recognize and attack various types of solid and hematologic cancers. Kite, in collaboration with its partners, is currently advancing several TCR-engineered T cell programs that target cancer-specific proteins such as cancer testis antigens, viral antigens and neo antigens. Kite is also leveraging its proprietary TCR-GENErator™ discovery platform for rapid, high-throughput identification of TCR-based product candidates.