Mouse Brain Circuit ; Fear Control (Credit: CSHL/ Bo Li).
A team of researchers at CSHL has discovered a novel circuit in the mouse brain that controls fear. The red cells are neurons identified by a “trans-synaptic tracing technique”, which allows scientists to trace the neuronal circuit between two regions of the brain (shown here, called the PVT and CeL). Disrupting the circuit is enough to dramatically reduce fear, while strengthening the neuronal interactions can trigger an unwarranted fear response. The researchers suggest that this circuit represents an ideal target for new therapies to treat anxiety disorders (Credit: CHSL/Bo Li).