Pharmacokinetic Profile [Schematic Projection of Medchem Variables] (Credit: Michael M. Hann)

Pharmacokinetic Profile [Schematic Projection of Medchem Variables] (Credit: Michael M. Hann)

A successful pharmacokinetic profile meets at the intersection of 6 characteristics: potency, safety, stability, specificity, absorption, and solubility [Schematic projection of medchem variables into a 2D principal component space representation of the high dimensional property space that drug discovery takes place in. Excerpt from “Molecular obesity, potency and other addictions in drug discovery”; Michael M. Hann.]