(Figure 7B) PF Reduces IGF-1/PKA to Promote Lineage-Balanced Hematopoietic Regeneration

(Figure 7B) PF Reduces IGF-1/PKA to Promote Lineage-Balanced Hematopoietic Regeneration

PF Reduces IGF-1/PKA to Promote Lineage-Balanced Hematopoietic Regeneration

(B) A simplified model for PF-induced effects on WBC and HSCs. Fasting causes a major reduction in WBCs followed by their replenishment after refeeding, based on effects on HSCs self-renewal resulting in increased progenitor and immune cells. These effects of PF can result in reversal of chemotherapy-based immunosuppression but
also in the rejuvenation of the immune cell profile in old mice.