Space-Grown Crystals May Shed Light On Huntington’s Disease
A novel experiment to study the so-called Huntingtin protein arrived at its orbital laboratory on the International Space Station on April 20 along with 5,000 lbs. (2,268 kilograms) of cargo delivered on board SpaceX’s Dragon capsule.
When mutated, the huntingtin protein causes Huntington’s disease, a hereditary illness that impairs muscle control and cognition. There is no cure for the disorder, which is typically diagnosed in mid-adult life. For now, Huntington’s disease is “essentially a death sentence,” Gwen Owens, a Caltech graduate student who designed the experiment, said in a video. [Weird Space Science on SpaceX’s Dragon Ship (Infographic)]
To understand how proteins function, scientists often use a technique called X-ray crystallography, which allows them to peer at the molecular structure of the protein when it’s in a solid crystal form. So far, researchers haven’t had much luck creating crystals of the huntingtin protein on the ground, but Owens explained that crystals tend to grow more effectively in microgravity.
“On the ISS, we really hope to be able to finally get crystals that are big enough and perfect enough that we can solve the structure of the huntingtin protein,” Owen said in the video.
If the experiment works, the huntingtin crystals will be brought back to Earth this fall to be studied in an X-ray crystallography lab.
SpaceX, a private company based in Hawthorne, Calif., launched the Dragon resupply ship toward the International Space Station on Friday (April 18) from Cape Canaveral Air Force Station in Florida using its own Falcon 9 rocket. The mission was SpaceX’s third of 12 cargo delivery missions under a $1.6 billion contract with NASA.
Author: Megan Gannon. Originally published on Space.com.